Collie eye anomaly: a review A. (2015): Collie eye anomaly: a review. Veterinarni Medicina, 60: 345-350.
download PDF
Collie eye anomaly (CEA) is an inherited congenital visual impairment with heterogeneous signs. The first symptoms are already visible in the early embryo. Among the most affected breeds are Collies and Shetland Sheepdogs but the disease has spread to different breeds depending on the country of origin. Dogs affected with this disease share a 7.8 kb deletion in intron 4 of the NHEJ1 gene. Inheritance of this disease is autosomal recessive with incomplete penetrance. Thanks to a commercially available genetic test breeders can identify genetically affected recessive homozygotes and clinically healthy but genetic carriers of the mutation and thus select healthy parents for the next generation of dogs. However, the exact cause of the disease is not known and it is not known whether the causative mutation influences the occurrence of some other diseases (e.g. immunodeficiencies).
BARNETT K. C., STADES F. C. (1979): Collie eye anomaly in the Shetland Sheepdog in The Netherlands. Journal of Small Animal Practice, 20, 321-329
Barrie KP, Lavach JD, Gelatt KN (1981): Diseases of the canine posterior segment. In: Gelatt KN (ed.): Textbook of Veterinary Ophthalmology. Lea & Febiger, Philadelphia. 480–483.
Bedford PGC (1982a): Collie eye anomaly in the border collie. Veterinary Record 111, 34–35.
Bedford PGC (1982b): Collie eye anomaly in the United Kingdom. Veterinary Record 111, 263–270.
Bedford P. G. C. (1998): Collie eye anomaly in the Lancashire heeler. Veterinary Record, 143, 354-356
Bjerkås E. (1991): Collie eye anomaly in the rough collie in Norway. Journal of Small Animal Practice, 32, 89-92
Chang H.-S., Mizukami K., Yabuki A., Hossain M. A., Rahman M. M., Uddin M. M., Arai T., Yamato O. (2010): A Novel Rapid Genotyping Technique for Collie Eye Anomaly: SYBR Green-Based Real-Time Polymerase Chain Reaction Method Applicable to Blood and Saliva Specimens on Flinders Technology Associates Filter Paper. Journal of Veterinary Diagnostic Investigation, 22, 708-715
Dakubo G. D. (): Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development, 130, 2967-2980
Donovan EF, Wyman M (1965): Ocular fundus anomaly in the Collie. Journal of the American Veterinary Medical Association 147, 1465–1469.
Donovan RH, Freeman HM, Schepens CL (1969): Anomaly of the Collie eye. Journal of the American Veterinary Medical Association 155, 872–875.
Dostal J, Horak P, Hrdlicova A, Stratil A (2010): Simplified PCR analysis of a mutation in the NHEJ1 gene causing collie eye anomaly in some dog breeds. Czech Journal of Animal Science 8, 346–350.
Ingham P. W. (): Hedgehog signaling in animal development: paradigms and principles. Genes & Development, 15, 3059-3087
Latshaw WK, Wyman M, Venzke WG (1969): Embryonic development of an anomaly of ocular fundus in collie dog. American Journal of Veterinary Research 30, 211–217.
Leppanen , Saloniemi (1998): Screening and controlling canine inherited ocular diseases in Finland: epidemiological, economical and health promotional aspect. Veterinary Ophthalmology, 1, 203-210
Lowe Jennifer K., Kukekova Anna V., Kirkness Ewen F., Langlois Mariela C., Aguirre Gustavo D., Acland Gregory M., Ostrander Elaine A. (2003): Linkage mapping of the primary disease locus for collie eye anomaly☆. Genomics, 82, 86-95
Magrane W (1953): Congenital anomaly of the optic nerve in Collies. North American Veterinarian 34, 646–647.
Mizukami Keijiro, Chang Hye-Sook, Ota Mitsuharu, Yabuki Akira, Hossain Mohammand A., Rahman Mohammad M., Uddin Mohammad M., Yamato Osamu (2012): Collie eye anomaly in Hokkaido dogs: case study. Veterinary Ophthalmology, 15, 128-132
Munyard Kylie A., Sherry Colin R., Sherry Lesley (2007): A retrospective evaluation of congenital ocular defects in Australian Shepherd dogs in Australia. Veterinary Ophthalmology, 10, 19-22
O'Driscoll M. (): Diseases Associated with Defective Responses to DNA Damage. Cold Spring Harbor Perspectives in Biology, 4, a012773-a012773
Parker H. G., Kukekova A. V., Akey D. T., Goldstein O., Kirkness E. F., Baysac K. C., Mosher D. S., Aguirre G. D., Acland G. M., Ostrander E. A. (2007): Breed relationships facilitate fine-mapping studies: A 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds. Genome Research, 17, 1562-1571
Roberts Seymour R. (1967): Color Dilution and Hereditary Defects in Collie Dogs. American Journal of Ophthalmology, 63, 1762-1775
Rubin LF (1969): Comments. Journal of the American Veterinary Medical Association 155, 865–866.
Sargan David R. (2001): Collie eye anomaly in the rough collie. Journal of Small Animal Practice, 42, 204-204
Stades F. C., Barnett K. C. (1981): Collie eye anomaly in Collies in the Netherlands. Veterinary Quarterly, 3, 66-73
Wallin-Håkanson B., Wallin-Håkanson N., Hedhammar Å. (2000): Collie eye anomaly in the rough collie in Sweden: genetic transmission and influence on offspring vitality. Journal of Small Animal Practice, 41, 254-258
Woodbine Lisa, Gennery Andrew R., Jeggo Penny A. (2014): The clinical impact of deficiency in DNA non-homologous end-joining. DNA Repair, 16, 84-96
Yakely WL (1972): Collie eye anomaly: Decreased prevalence through selective breeding. Journal of the American Veterinary Medical Association 161, 1103–1107.
Yakely WL, Wyman M, Donovan EF, Fechheimer NS (1968): Genetic transmission of an ocular fundus anomaly in Collies. Journal of the American Veterinary Medical Association 152, 457–461.
download PDF

© 2021 Czech Academy of Agricultural Sciences | Prohlášení o přístupnosti