The aim of this study was to evaluate the effects of administration of oxytocin, in combination with dinoprost or ergometrin, after parturition on the occurrence of clinical endometritis and subsequent reproductive performance in dairy cows. The cows, without retained foetal membranes, were assigned to one of three groups. No treatment was performed in the control group (Group C, n = 229). However, intramuscular administrations of oxytocin (30 IU) on Days 1 and 2 post partum, in combination with dinoprost (25 mg, Group D, n = 123) or ergometrin (15 mg, Group E, n = 130) administered on Day 7 post partum, were performed in experimental groups. Vaginal discharge score (VDS, 1–5), uterine content score (UCS, 1–3) on Day14 to 21 post partum, number of treatment interventions (TI), proportion of non-treated cows (NT) because of endometritis, calving to first insemination interval (CI), first insemination conception rate (CR), and proportion of pregnant cows by Day 150 post partum (PC), were compared among groups. There was no significant difference among groups for any parameter. Average values were 2.08, 2.24 and 2.06 (VDS); 1.49, 1.51 and 1.45 (UCS); 0.86, 0.93 and 0.74 (TI); 59.4, 54.2 and 54.7% (NT); 73.9 ± 15.2, 75.4 ± 17 and 74.2 ± 17 days (CI); 41.4, 38.9 and 44.3% (CR); and 75.4, 77.7 and 80.5% (PC) for Groups C, D and E, respectively. There was no significant benefit of preventive administration of oxytocin, in combination with dinoprost or ergometrin, after parturition on reproductive performance in dairy cows.
Bajcsy Árpád Csaba, Szenci Ottó, Weijden Gijsbert C. van der, Doornenbal Arie, Maassen Francesca, Bartyik János, Taverne Marcel A.M. (2006): The effect of a single oxytocin or carbetocin treatment on uterine contractility in early postpartum dairy cows. Theriogenology, 65, 400-414 https://doi.org/10.1016/j.theriogenology.2005.05.040
Barrett A. J., Murray R. D., Christley R. M., Dobson H., Smith R. F. (2009): Effects of the administration of oxytocin or carbetocin to dairy cows at parturition on their subsequent fertility. Veterinary Record, 165, 623-626 https://doi.org/10.1136/vr.165.21.623
Borsberry S., Dobson H. (1989): Periparturient diseases and their effect on reproductive performance in five dairy herds. Veterinary Record, 124, 217-219 https://doi.org/10.1136/vr.124.9.217
Dolezel R, Vecera M, Palenik T, Cech S, Vyskocil M (2008): Systematic clinical examination of early postpartum cows and treatment of puerperal metritis did not have any beneficial effect on subsequent reproductive performance. Veterinarni Medicina 53, 59–69.
Dubuc J., Duffield T.F., Leslie K.E., Walton J.S., LeBlanc S.J. (2011): Randomized clinical trial of antibiotic and prostaglandin treatments for uterine health and reproductive performance in dairy cows. Journal of Dairy Science, 94, 1325-1338 https://doi.org/10.3168/jds.2010-3757
Fourichon C., Seegers H., Malher X. (2000): Effect of disease on reproduction in the dairy cow: a meta-analysis. Theriogenology, 53, 1729-1759 https://doi.org/10.1016/S0093-691X(00)00311-3
Gajewski Z, Thun R, Faundez R, Boryczko Z (1999): Uterine Motility in the Cow During Puerperium. Reproduction in Domestic Animals, 34, 185-191 https://doi.org/10.1111/j.1439-0531.1999.tb01239.x
Haimerl P., Heuwieser W., Arlt S. (2013): Therapy of bovine endometritis with prostaglandin F2α: A meta-analysis. Journal of Dairy Science, 96, 2973-2987 https://doi.org/10.3168/jds.2012-6154
Hickey G., White M., Wickenden R., Armstrong D. (1984): Effects of oxytocin on placental retention following dystocia. Veterinary Record, 114, 189-190 https://doi.org/10.1136/vr.114.8.189
Hirsbrunner G, Küpfer U, Burkhardt H, Steiner A (1998): Effect of different prostaglandins on intrauterine pressure and uterine motility during diestrus in experimental cows. Theriogenology, 50, 445-455 https://doi.org/10.1016/S0093-691X(98)00151-4
Kaufmann T.B., Westermann S., Drillich M., Plöntzke J., Heuwieser W. (2010): Systemic antibiotic treatment of clinical endometritis in dairy cows with ceftiofur or two doses of cloprostenol in a 14-d interval. Animal Reproduction Science, 121, 55-62 https://doi.org/10.1016/j.anireprosci.2010.04.190
Kaya D, Ay SS, Kucukaslan I, Beceriklisoy HB, Agaoglu AR, Findik M, Ozyurtlu N, Aslan S (2012): The effectiveness of combined preventive treatment with ceftiofur, oxytocin and PGF2α on fertility parameters in cows. Revue de Medecine Veterinaire 163, 302–308.
Kudlac E, Zamecnik B (1984): Effects of carbetocin (Depotocin inj. Spofa) on prevention of retained placenta in postpartum cows (in Czech). Biologizace a chemizace zivocisne vyroby – veterinaria 20, 131–140.
McClary D.G., Putnam M.R., Wright J.C., Sartin J.L. (1989): Effect of early postpartum treatment with prostaglandin F2α on subsequent fertility in the dairy cow. Theriogenology, 31, 565-570 https://doi.org/10.1016/0093-691X(89)90241-0
McDougall S., Macaulay R., Compton C. (2007): Association between endometritis diagnosis using a novel intravaginal device and reproductive performance in dairy cattle. Animal Reproduction Science, 99, 9-23 https://doi.org/10.1016/j.anireprosci.2006.03.017
McDougall Scott, de Boer Melvin, Compton Chris, LeBlanc Stephen J. (2013): Clinical trial of treatment programs for purulent vaginal discharge in lactating dairy cattle in New Zealand. Theriogenology, 79, 1139-1145 https://doi.org/10.1016/j.theriogenology.2013.02.002
McLaughlin C.L., Stanisiewski E.P., Risco C.A., Santos J.E.P., Dahl G.E., Chebel R.C., LaGrow C., Daugherty C., Bryson L., Weigel D., Hallberg J., Lucas M.J. (2013): Evaluation of ceftiofur crystalline free acid sterile suspension for control of metritis in high-risk lactating dairy cows. Theriogenology, 79, 725-734 https://doi.org/10.1016/j.theriogenology.2012.11.029
Mollo A., Veronesi M.C., Cairoli F., Soldano F. (1997): The use of oxytocin for the reduction of cow placental retention, and subsequent endometritis. Animal Reproduction Science, 48, 47-51 https://doi.org/10.1016/S0378-4320(97)00038-9
Palomares R.A., Gutiérrez J.C., Portillo G., Boscan J.C., Montero M., López Y., Maxwell H.S., Carson R.L., Soto E. (2010): Oxytocin treatment immediately after calving does not reduce the incidence of retained fetal membranes or improve reproductive performance in crossbred Zebu cows. Theriogenology, 74, 1414-1419 https://doi.org/10.1016/j.theriogenology.2010.06.013
Sheldon I. Martin, Lewis Gregory S., LeBlanc Stephen, Gilbert Robert O. (2006): Defining postpartum uterine disease in cattle. Theriogenology, 65, 1516-1530 https://doi.org/10.1016/j.theriogenology.2005.08.021
Sheldon I. Martin, Williams Erin J., Miller Aleisha N.A., Nash Deborah M., Herath Shan (2008): Uterine diseases in cattle after parturition. The Veterinary Journal, 176, 115-121 https://doi.org/10.1016/j.tvjl.2007.12.031
Tsousis G, Sharifi AR, Hoedemaker M (2010): Increased Risk of Conception Failure in German Holstein Friesian Cows with Chronic Endometritis. Reproduction in Domestic Animals, 45, 1114-1117 https://doi.org/10.1111/j.1439-0531.2009.01481.x
Williams EJ (2013): Drivers of Post-partum Uterine Disease in Dairy Cattle. Reproduction in Domestic Animals, 48, 53-58 https://doi.org/10.1111/rda.12205
Williams Erin J., Fischer Deborah P., Pfeiffer Dirk U., England Gary C.W., Noakes David E., Dobson Hilary, Sheldon I.Martin (2005): Clinical evaluation of postpartum vaginal mucus reflects uterine bacterial infection and the immune response in cattle. Theriogenology, 63, 102-117 https://doi.org/10.1016/j.theriogenology.2004.03.017
Young I.M., Anderson D.B. (1986): Improved reproductive performance from dairy cows treated with dinoprost tromethamine soon after calving. Theriogenology, 26, 199-208 https://doi.org/10.1016/0093-691X(86)90024-5