Antinociceptive mechanisms of Bunium persicum essential oil in the mouse writhing test: role of opioidergic and histaminergic systems

https://doi.org/10.17221/7988-VETMEDCitation:Zendehdel M., Torabi Z., Hassanpour S. (2015): Antinociceptive mechanisms of Bunium persicum essential oil in the mouse writhing test: role of opioidergic and histaminergic systems. Veterinarni Medicina, 60: 63-70.
download PDF
Bunium persicum (Boiss.) is an economically important medicinal plant growing wildly in arid regions in Iran. The fruit of B. persicum is widely used in traditional Iranian medicine to control colic pain and dysmenorrhoea. The aim of the current study was to determine antinociceptive mechanisms of B. persicum essential oil using an acetic acid-induced writhing test as a model of visceral pain and to determine the possible involvement of opioidergic, serotoninergic and histaminergic systems on antinociceptive mechanisms of B. persicum in male mice. In experiment 1, B. persicum was intraperitoneally (i.p.) injected (0.001, 0.01, 0.05, 0.1, 0.5 and 1%; 10 ml/kg) in Tween-80 (0.5%) and a writhing test served as a model of visceral pain. In experiments 2–5, opioidergic receptor antagonist (naloxone, 2 mg/kg), serotonergic receptor antagonist (cyproheptadine, 4 mg/kg), histamine H1-receptor antagonist (chlorpheniramine, 20 mg/kg) and histamine H2-receptor antagonist (cimetidine, 12.5mg/kg) injection was followed by B. persicum (0.01%; 10 ml/kg) and the writhing test response was measured for 30 min. According to the results, essential oil of B. persicum, administered i.p. (0.001, 0.01, 0.05, 0.1, 0.5, and 1%; 10 ml/kg) in Tween-80 (0.5%), elicited antinociceptive effects in a dose-dependent manner. Moreover, the antinociceptive effect of B. persicum was significantly attenuated by pre-treatment with naloxone, chlorpheniramine and cimetidine (P < 0.001). These results suggest that B. persicum-induced analgesia may be mediated via opioidergic and histamine H1 and H2 receptors.
References:
Ahmed F, Selim MST, Das AK, Choudhuri MSK (2004): Anti-inflammatory and antinociceptive activities of Lippia nodiflora Linn. Pharmazie 59, 329–333.
 
Ballou L. R., Botting R. M., Goorha S., Zhang J., Vane J. R. (2000): Nociception in cyclooxygenase isozyme-deficient mice. Proceedings of the National Academy of Sciences, 97, 10272-10276 https://doi.org/10.1073/pnas.180319297
 
Berkenkopf JW, Weichmann BM (1988): Production of prostaglandin in mice following intraperitoneal injection of acetic acid, phenyl benzoquinone and zymosan: Its role in the writhing response. Prostaglandins 36, 693–709.
 
Bero LA, Kuhn CM (1987): Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat. Journal of Pharmacology and Experimental Therapeutics 240, 831–834.
 
Bodnar Richard J. (2009): Endogenous opiates and behavior: 2008. Peptides, 30, 2432-2479 https://doi.org/10.1016/j.peptides.2009.09.027
 
Boskabady MH, Talebi M (1999): Bronchodilatory and anticholinergic effects of Carum carvi on isolated guinea-pig tracheal chains. Medical Journal of Iran 12, 345–351.
 
Brown Ritchie E., Stevens David R., Haas Helmut L. (2001): The physiology of brain histamine. Progress in Neurobiology, 63, 637-672 https://doi.org/10.1016/S0301-0082(00)00039-3
 
Choi Seong-Soo, Han Ki-Jung, Lee Jin-Koo, Lee Han-Kyu, Han Eun-Jung, Kim Do-Hoon, Suh Hong-Won (2003): Antinociceptive mechanisms of orally administered decursinol in the mouse. Life Sciences, 73, 471-485 https://doi.org/10.1016/S0024-3205(03)00311-4
 
Chung Y. H., Miyake H., Kamei C., Tasaka K. (1984): Analgesic effect of histamine induced by intracerebral injection into mice. Agents and Actions, 15, 137-142 https://doi.org/10.1007/BF01972339
 
Collier HOJ, Dinneen LC, Johnson CA, Schneide C (1968): Abdominal constriction response and its suppression by analgesic drugs in mouse. British Journal of Pharmacology 32, 295–310.
 
de Sousa Orlando Vieira, Vieira Glauciemar Del-Vechio, de Pinho José de Jesus R. G., Yamamoto Célia Hitomi, Alves Maria Silvana (2010): Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models. International Journal of Molecular Sciences, 11, 2067-2078 https://doi.org/10.3390/ijms11052067
 
Demirci F., Guven K., Demirci B., Dadandi M.Y., Baser K.H.C. (2008): Antibacterial activity of two Phlomis essential oils against food pathogens. Food Control, 19, 1159-1164 https://doi.org/10.1016/j.foodcont.2008.01.001
 
Duke JA, Bogenschutz-Godwin MJ, Ducellier J (2002): CRC Handbook of Medicinal Spices. CRC Press, Boca Raton, FL.
 
Elisabetsky E, Souza GPC, Santos MAC Siqueira IR, Amador TA (1995): Sedative properties of Linalool. Fitoterapia 115, 407–414.
 
Giamberardino Maria Adele (1999): Recent and forgotten aspects of visceral pain. European Journal of Pain, 3, 77-92 https://doi.org/10.1053/eujp.1999.0117
 
Golshani S, Karamkhani F, Monsef-Esfehani HR, Abdollahi M (2004): Antinociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test. Journal of Pharmacy and Pharmaceutical Science 7, 76–79.
 
Gray A M, Spencer P S J, Sewell R D E (1998): The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. British Journal of Pharmacology, 124, 669-674 https://doi.org/10.1038/sj.bjp.0701882
 
Guilhon Carolina C., Raymundo Larissa J.R.P., Alviano Daniela S., Blank Arie F., Arrigoni-Blank Maria F., Matheus Maria Eline, Cavalcanti Sócrates C.H., Alviano Celuta S., Fernandes Patrícia D. (2011): Characterisation of the anti-inflammatory and antinociceptive activities and the mechanism of the action of Lippia gracilis essential oil. Journal of Ethnopharmacology, 135, 406-413 https://doi.org/10.1016/j.jep.2011.03.032
 
Hajhashemi V, Sajjadi S, Zomorodkia M (2011a): Antinociceptive and anti-inflammatory activities of Bunium persicum essential oil, hydroalcoholic and polyphenolic extracts in animal models. Pharmaceutical Biology 49, 146–151.
 
Hajhashemi V, Zolfaghari B, Yousefi A (2011b): Antinociceptive and anti-inflammatory activities of Satureja hortensis seed essential oil, hydroalcoholic and polyphenolic extracts in animal models. Medical Principles and Practice 21, 178–182.
 
Hasan S.M. Raquibul, Jamila Mariam, Majumder Muntasir Mamun, Akter Raushanara, Hossain Md. Mokarram, Mazumder Md. Ehsanul Hoque, Alam Md. Ashraful, Jahangir Rumana, Rana Md. Sohel, Arif Md., Rahman Shafiqur (2009): Analgesic and Antioxidant Activity of the Hydromethanolic Extract of Mikania scandens (L.) Willd. Leaves. American Journal of Pharmacology and Toxicology, 4, 1-7 https://doi.org/10.3844/ajptsp.2009.1.7
 
Hosseinzadeh H, Younesi H (2002): Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacology 2, 1–8.
 
Illouz G, Delbarre F (1964): Para-cymene, an analgesic drug with percutaneous action. La Semaine des Hopitaux 40, 2902–2903.
 
Inturrisi CE (2002): Clinical pharmacology of opioids for pain. Clinical Journal of Pain 18 Suppl., S3–S13.
 
Kochhar KP (2008): Dietary spices in Health and diseases. Indian Journal of Physiology and Pharmacology 52, 327–354.
 
Koster R, Anderson M, De Beer EJ (1959): Acetic acid for analgesic screening. Federation Proceedings 18, 418–420.
 
Kozak W, Archuleta I, Mayfield KP, Kozak A, Rudolph K, Kluger MJ (1998): Inhibition of alternative pathways of arachidonate metabolism differentially affects fever in mice. American Journal of Physiology 275, R1031–R1040.
 
Levine J, Taiwo Y (1994): Inflammatory pain. In: Wall PD, Melzack R (eds.): Textbook of Pain. 3rd ed., Churchill Livingstone, New York. 45–56.
 
Leza JC, Lizasoain I, Lorenzo P (1990): H1- and H2-histamine receptor blockers and opiate analgesia in mice. Methods and Findings in Experimental Clinical Pharmacology 12, 671–678.
 
Malmberg-Aiello Petra, Lamberti Claudia, Ghelardini Carla, Giotti Alberto, Bartolini Alessandro (1994): Role of histamine in rodent antinociception. British Journal of Pharmacology, 111, 1269-1279 https://doi.org/10.1111/j.1476-5381.1994.tb14883.x
 
Mattison Nancy, Gene Trimble A, Lasagna Louis (1988): New drug development in the United States, 1963 through 1984. Clinical Pharmacology and Therapeutics, 43, 290-301 https://doi.org/10.1038/clpt.1988.35
 
Mendes S.S., Bomfim R.R., Jesus H.C.R., Alves P.B., Blank A.F., Estevam C.S., Antoniolli A.R., Thomazzi S.M. (2010): Evaluation of the analgesic and anti-inflammatory effects of the essential oil of Lippia gracilis leaves. Journal of Ethnopharmacology, 129, 391-397 https://doi.org/10.1016/j.jep.2010.04.005
 
Milde J., Elstner E.F., Graßmann J. (2004): Synergistic inhibition of low-density lipoprotein oxidation by rutin, γ-terpinene, and ascorbic acid. Phytomedicine, 11, 105-113 https://doi.org/10.1078/0944-7113-00380
 
Mobarakeh JI, Sakurada S, Katsuyama S, Kutsuwa M, Kuramasu A, Takeshi, ZY, Hashimoto WY, Watanabe T, Yanai K (2000): Role of histamine H1 receptor in pain perception: a study of the receptor gene knockout mice. Journal of Ethnopharmacology 391, 81–89.
 
Moghtader M, Mansori AI, Salari H, Farahmand A (2009): Chemical composition and antimicrobial activity of the essential oil of Bunium persicum Bioss. seed. Iranian Journal of Medicinal and Aromatic Plants 25, 20–28.
 
Mojtahedin A, Tamaddonfard E, Zanboori A (2008): Antinociception induced by central administration of histamine in the formalin test in rats. Indian Journal of Physiology and Pharmacology 52, 249–254.
 
N'gouemo P., Baldy-Moulinier M., Nguemby-Bina C. (1996): Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents. Journal of Ethnopharmacology, 52, 77-83 https://doi.org/10.1016/0378-8741(96)01389-X
 
Oroojalian F., Kasra-Kermanshahi R., Azizi M., Bassami M.R. (2010): Phytochemical composition of the essential oils from three Apiaceae species and their antibacterial effects on food-borne pathogens. Food Chemistry, 120, 765-770 https://doi.org/10.1016/j.foodchem.2009.11.008
 
Peana Alessandra T, D'Aquila Paolo S, Chessa M.Loredana, Moretti Mario D.L, Serra Gino, Pippia Proto (2003): (−)-Linalool produces antinociception in two experimental models of pain. European Journal of Pharmacology, 460, 37-41 https://doi.org/10.1016/S0014-2999(02)02856-X
 
Reisine T, Pasternak G (1996): Opioid analgesics and antagonists. In: Goodman LS, Gilman AG (eds.): The Pharmacological Basis of Therapeutics. McGraw-Hill, New York. pp. 521–556.
 
Robertson Judith A., Hough Lindsay B., Richard J. Bodnar (1988): Potentiation of opioid and nonopioid forms of swim analgesia by cimetidine. Pharmacology Biochemistry and Behavior, 31, 107-112 https://doi.org/10.1016/0091-3057(88)90320-6
 
Santos F. A., Rao V. S. N. (2000): Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phytotherapy Research, 14, 240-244 https://doi.org/10.1002/1099-1573(200006)14:4<240::AID-PTR573>3.0.CO;2-X
 
Santos F.A., Jeferson F.A., Santos C.C., Silveira E.R., Rao V.S.N. (2005): Antinociceptive effect of leaf essential oil from Croton sonderianus in mice. Life Sciences, 77, 2953-2963 https://doi.org/10.1016/j.lfs.2005.05.032
 
Satyanarayana Padi S.V., Jain Naveen K., Singh Amarjit, Kulkarni Shrinivas K. (2004): Isobolographic analysis of interaction between cyclooxygenase inhibitors and tramadol in acetic acid-induced writhing in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 28, 641-649 https://doi.org/10.1016/j.pnpbp.2004.01.015
 
Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjork HE (1997): Specific C receptors for itch in human skin. Journal of Neuroscience 17, 8003–8008.
 
Schmitt H, Le Douarec JC, Petillot N (1974): Antagonism of the antinociceptive action of xylazine, an α-sympatho-
 
mimetic agent, by adrenoceptor and cholinoceptor blocking agents. Neuropharmacology 13, 295–303.
 
Schwartz JC, Arrange JM, Garbarg M, Pollard H, Ruat M (1991): Histaminergic transmission in mammalian brain. Physiological Reviews 71, 1–51.
 
Shahsavari Neda, Barzegar Mohsen, Sahari Mohammad Ali, Naghdibadi Hasanali (2008): Antioxidant Activity and Chemical Characterization of Essential Oil of Bunium persicum. Plant Foods for Human Nutrition, 63, 183-188 https://doi.org/10.1007/s11130-008-0091-y
 
Sofi PA, Zeerak NA, Singh P (2009): Kala zeera (Bunium persicum Bioss.): a Kashmirian high value crop. Turkish Journal of Biology 33, 249–258.
 
Sulaiman M.R., Hussain M.K., Zakaria Z.A., Somchit M.N., Moin S., Mohamad A.S., Israf D.A. (2008): Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract. Fitoterapia, 79, 557-561 https://doi.org/10.1016/j.fitote.2008.06.005
 
Takayuki S, Sugano M, Azizi M, Yoshiharu F (2007): Antifungal effects of volatile compounds from black zira (Bunium persicum) and other spices and herbs. Journal of Chemical Ecology 33, 11, 2123–2132.
 
Thoburn Kathleen K., Hough Lindsay B., Nalwalk Julia W., Mischler Scott A. (1994): Histamine-induced modulation of nociceptive responses. Pain, 58, 29-37 https://doi.org/10.1016/0304-3959(94)90182-1
 
Trescot AM, Datta S, Lee M, Hansen H (2008): Opioid Pharmacology. Pain Physician 11, 133–153.
 
Van Riezen H (1972): Differential central effect of the 5-HT antagonist mianserin and cyproheptadine. Archives Internationales de Pharmacodynamie 198, 256–260.
 
Wang Rui, Wang Ruijiang, Yang Bao (2009): Extraction of essential oils from five cinnamon leaves and identification of their volatile compound compositions. Innovative Food Science & Emerging Technologies, 10, 289-292 https://doi.org/10.1016/j.ifset.2008.12.002
 
Zargari A (1996): Medicinal Plants. Tehran University Publications; 2, 509–515.
 
Zendehdel M, Babapour V (2010): Study of antinociceptive effects of Ziziphora tenuior and its interference on opioidergic and serotoninergic systems. Journal of Veterinary Research 65, 57–60.
 
Zendehdel M, Taati M, Jadidoleslami M, Bashiri A (2011): Evaluation of pharmacological mechanisms of antinociceptive effect of Teucrium polium on visceral pain in mice. Iranian Journal of Veterinary Research 12, 292–297.
 
Zendehdel M, Taati M, Amoozad M, Hamidi F (2012): Antinociceptive effect of the aqueous extract obtained from Foeniculum vulgare in mice: the role of histamine H1 and H2 receptors. Iranian Journal of Veterinary Research 13, 100–106.
 
Zimmermann Manfred (1983): Ethical guidelines for investigations of experimental pain in conscious animals. Pain, 16, 109-110 https://doi.org/10.1016/0304-3959(83)90201-4
 
download PDF

© 2018 Czech Academy of Agricultural Sciences