Pulmonary Mycobacterium tuberculosis infection with giant tubercle formation in a dog: a case report

https://doi.org/10.17221/8724-VETMEDCitation:Park H.A., Lim J.H., Kwon Y.H., Bae J.H., Park H.M. (2016): Pulmonary Mycobacterium tuberculosis infection with giant tubercle formation in a dog: a case report. Veterinarni Medicina, 61: 102-109.
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An eight-year-old, 4.9 kg, intact male mongrel dog presented with progressive weight loss, anorexia, vomiting, diarrhoea, and open-mouth breathing. A thoracic radiograph showed significant pleural effusion. Upon removal of the pleural effusion, an oval-shaped soft-tissue density mass was identified above the heart base. Two months later, the dog’s condition worsened severely, and he was euthanised. A complete necropsy showed all intrathoracic structures were encapsulated by a fibrinous material. A large granuloma was attached between the right cranial lung lobe and the trachea. The cytological evaluation of the pleural effusion showed numerous negative-staining rod structures. Ziehl-Neelsen staining confirmed the presence of acid-fast bacilli. A polymerase chain reaction test confirmed Mycobacterium tuberculosis infection. This work is the first case report of canine pulmonary M. tuberculosis infection in South Korea. To the best of our knowledge, the formation of giant tubercles in canine pulmonary tuberculosis has not been reported recently.

Baynes R D, Bothwell T H, Flax H, McDonald T P, Atkinson P, Chetty N, Bezwoda W R, Mendelow B V (1987): Reactive thrombocytosis in pulmonary tuberculosis.. Journal of Clinical Pathology, 40, 676-679  https://doi.org/10.1136/jcp.40.6.676
Engelmann N., Ondreka N., Michalik J., Neiger R. (2014): Intra-abdominal Mycobacterium tuberculosis Infection in a Dog. Journal of Veterinary Internal Medicine, 28, 934-938  https://doi.org/10.1111/jvim.12347
Etienne Claire-Lise, Granat Fanny, Trumel Catherine, Raymond-Letron Isabelle, Lucas Marie-Noëlle, Boucraut-Baralon Corine, Pingret Jean-Luc, Magne Laurent, Delverdier Maxence (2013): A mycobacterial coinfection in a dog suspected on blood smear. Veterinary Clinical Pathology, 42, 516-521  https://doi.org/10.1111/vcp.12088
Foster ES, Scavelli TD, Greenlee PG, Gilbertson SR (1986): Cutaneous lesion caused by Mycobacterium tuberculosis in a dog. Journal of the American Veterinary Medical Association 188, 1188–1190.
Gay G., Burbidge H.M., Bennett P., Fenwick S.G., Dupont C., Murray A. (2000): Pulmonary Mycobacterium bovis infection in a dog. New Zealand Veterinary Journal, 48, 78-81  https://doi.org/10.1080/00480169.2000.36164
Hackendahl Nicole C., Mawby Dianne I., Bemis David A., Beazley Shelley L. (2004): Putative transmission of Mycobacterium tuberculosis infection from a human to a dog. Journal of the American Veterinary Medical Association, 225, 1573-1577  https://doi.org/10.2460/javma.2004.225.1573
Koseoglu Mehmet, Hur Aysel, Atay Aysenur, Cuhadar Serap (): Effects of hemolysis interference on routine biochemistry parameters. Biochemia Medica, , 79-85  https://doi.org/10.11613/BM.2011.015
LIGHT Richard W. (2010): Update on tuberculous pleural effusion. Respirology, 15, 451-458  https://doi.org/10.1111/j.1440-1843.2010.01723.x
Martinho A. P. V., Franco M. M. J., Ribeiro M. G., Perrotti I. B. M., Mangia S. H., Megid J., Vulcano L. C., Lara G. H. B., Santos A. C. B., Leite C. Q. F., de Carvalho Sanches O., Paes A. C. (): Disseminated Mycobacterium tuberculosis Infection in a Dog. American Journal of Tropical Medicine and Hygiene, 88, 596-600  https://doi.org/10.4269/ajtmh.12-0332
Moritz Andreas, Fickenscher Yvonne, Meyer Karin, Failing Klaus, Weiss Douglas J. (2004): Canine and feline hematology reference values for the ADVIA 120 hematology system. Veterinary Clinical Pathology, 33, 32-38  https://doi.org/10.1111/j.1939-165X.2004.tb00347.x
Pang Daniel S., Boysen Søren (2007): Lactate in Veterinary Critical Care: Pathophysiology and Management. Journal of the American Animal Hospital Association, 43, 270-279  https://doi.org/10.5326/0430270
Parsons S.D.C., Gous T.A., Warren R.M., Van Helden P.D. (2008): Pulmonary Mycobacterium tuberculosis (Beijing strain) infection in a stray dog : clinical communication. Journal of the South African Veterinary Association, 79, -  https://doi.org/10.4102/jsava.v79i2.252
Posthaus H., Bodmer T., Alves L., Oevermann A., Schiller I., Rhodes S.G., Zimmerli S. (2011): Accidental infection of veterinary personnel with Mycobacterium tuberculosis at necropsy: A case study. Veterinary Microbiology, 149, 374-380  https://doi.org/10.1016/j.vetmic.2010.11.027
Sharma SK, Mohan A, Sharma A (2012): Challenges in the diagnosis and treatment of miliary tuberculosis. Indian Journal of Medical Research 135, 703-730.
Stockham SL, Scott MA (2008): Fundamental of Veterinary Clinical Pathology. 2nd ed. Blackwell. 54–100, 370–405, 640–669.
Sykes Jane E., Cannon Allison B., Norris Aimee J., Byrne Barbara A., Affolter Timothy, O'Malley Michael A., Wisner Erik R. (2007): Mycobacterium tuberculosis Complex Infection in a Dog. Journal of Veterinary Internal Medicine, 21, 1108-1112  https://doi.org/10.1111/j.1939-1676.2007.tb03072.x
Turinelli V., Ledieu D., Guilbaud L., Marchal T., Magnol J. P., Fournel-Fleury C. (2004): Mycobacterium tuberculosis infection in a dog from Africa. Veterinary Clinical Pathology, 33, 177-181  https://doi.org/10.1111/j.1939-165X.2004.tb00371.x
Unsal E (2005): Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis. Postgraduate Medical Journal, 81, 604-607  https://doi.org/10.1136/pgmj.2004.030544
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