The objective of this study was to compare, in client-owned patients, the analgesic effects of the centrally acting analgesics tramadol and buprenorphine in continuous intravenous anaesthesia (TIVA) with propofol. The study included forty dogs aged two to seven years and weighing 6–27 kg undergoing prophylactic dental treatment. The animals were classified into ASA (American Society of Anaesthesiologists) I. and II. risk groups. One group of dogs received intravenous administration of tramadol (2 mg/kg) and the second one buprenorphine (0.02 mg/kg) 30 min prior to sedation induced by midazolam (0.3 mg/kg) and xylazine (0.5 mg/kg) i.v. General anaesthesia was induced by propofol (2 mg/kg) and maintained by a 120-minute propofol infusion (0.2 mg/kg min). Arterial blood pressure, heart rate, respiratory rate, saturation of haemoglobin with oxygen, body temperature and deep pain sensation elicited by haemostat forceps pressure on the fingers were recorded at ten minute intervals. The tramadol group of dogs showed significantly better blood pressure values (P < 0.001), minimal tendency to bradycardia (P < 0.05) and respiratory rate (P < 0.001), without any negative effects on oxygen saturation. Significantly better deep pain sensation was achieved in the tramadol group (P < 0.001). Blood gas/acid base profile analysis showed a non-significant increase in the tramadol group of dogs. In conclusion, in comparison with buprenorphine, tramadol provided significantly better results with respect to degree of analgesia, as well as the tendency towards cardiopulmonary complications arising during anaesthesia. Significantly better analgesia and a lower depressive effect of tramadol on vital functions allows better control and management of the continuous intravenous propofol anaesthesia.
Bono AV, Cuffari S (1997): Effectiveness and tolerance of tramadol in cancer pain. A comparative study with respect to buprenorphine. Drugs, 53 (Suppl 2), 40–49.
Budd K, Raffa RB (2005): Buprenorphine – The Unique Opioid Analgesic. 1st ed. Thieme Stuttgard, New York. 132 pp.
Brayfield A (2014): Tramadol hydrochloride. In: Brayfield A (ed.): Martindale: The Complete Drug Reference. Pharmaceutical Press, London. 4688 pp.
Brema F, Pastorino G, Martini MC, Gottlieb A, Luzzani M, Libretti A, Sacca L, Gigolari S (1996): Oral tramadol and buprenorphine in tumour pain. An Italian multicentre trial. International Journal of Clinical Pharmacology Research 16, 109–116.
Dohoo SE, Dohoo IR (1996): Factors influencing the postoperative use of analgesics in dogs and cats by Canadian veterinarians. Canadian Veterinary Journal 37, 552–556
Duthie DJR. (1998): Remifentanil and tramadol. British Journal of Anaesthesia, 81, 51-57 https://doi.org/10.1093/bja/81.1.51
Grond Stefan, Sablotzki Armin (2004): Clinical Pharmacology of Tramadol. Clinical Pharmacokinetics, 43, 879-923 https://doi.org/10.2165/00003088-200443130-00004
Khan TH (2009): Safety of tramadol as a pre-induction agent. Anaesthesia Pain and Intensive Care 13, 57–60.
Kögel Babette, Terlinden Rolf, Schneider Johannes (2014): Characterisation of tramadol, morphine and tapentadol in an acute pain model in Beagle dogs. Veterinary Anaesthesia and Analgesia, 41, 297-304 https://doi.org/10.1111/vaa.12140
Lee C. Rhoda, McTavish Donna, Sorkin Eugene M. (1993): Tramadol. Drugs, 46, 313-340 https://doi.org/10.2165/00003495-199346020-00008
Manocha Anshu, Sharma Krishna Kishore, Mediratta Pramod Kumari (2005): On the mechanism of anticonvulsant effect of tramadol in mice. Pharmacology Biochemistry and Behavior, 82, 74-81 https://doi.org/10.1016/j.pbb.2005.07.013
Mastrocinque Sandra, Fantoni Denise T (2003): A comparison of preoperative tramadol and morphine for the control of early postoperative pain in canine ovariohysterectomy. Veterinary Anaesthesia and Analgesia, 30, 220-228 https://doi.org/10.1046/j.1467-2995.2003.00090.x
Moody D. E., Fang W. B., Lin S.-N., Weyant D. M., Strom S. C., Omiecinski C. J. (2009): Effect of Rifampin and Nelfinavir on the Metabolism of Methadone and Buprenorphine in Primary Cultures of Human Hepatocytes. Drug Metabolism and Disposition, 37, 2323-2329 https://doi.org/10.1124/dmd.109.028605
Paul-Murphy JR, Brunson DB, Miletic V (1999): Analgesic effects of butorphanol and buprenorphine in conscious African grey parrots (Psittacus erithacus erithacus and Psittacus erithacus timneh). American Journal of Veterinary Research 60, 1218–1221.
Raffa Robert B, Buschmann Helmut, Christoph Thomas, Eichenbaum Gary, Englberger Werner, Flores Christopher M, Hertrampf Torsten, Kögel Babette, Schiene Klaus, Straßburger Wolfgang, Terlinden Rolf, Tzschentke Thomas M (2012): Mechanistic and functional differentiation of tapentadol and tramadol. Expert Opinion on Pharmacotherapy, 13, 1437-1449 https://doi.org/10.1517/14656566.2012.696097
Reimann Wolfgang, Schneider Frank (1998): Induction of 5-hydroxytryptamine release by tramadol, fenfluramine and reserpine. European Journal of Pharmacology, 349, 199-203 https://doi.org/10.1016/S0014-2999(98)00195-2
Roughan J. V., Flecknell P. A. (2016): Buprenorphine: a reappraisal of its antinociceptive effects and therapeutic use in alleviating post-operative pain in animals. Laboratory Animals, 36, 322-343 https://doi.org/10.1258/002367702320162423
Spiller HA, Gorman SE, Villalobos D, Benson BE, Ruskosky DR, Stancavage, MM, Anderson DL (1997): Prospective multi-center evaluation of tramadol exposure. Journal of Toxicology: Clinical Toxicology 35, 361–364.
Siddiqui KM, Chohan U (2007): Tramadol versus Nalbuphine in total intravenous anaesthesia for dilatation and dvacuation. Journal of Pakistan Medical Association, 57, 67–70.
Stoelting RK (1999): Opioid agonists and antagonists. In: Stoelting RK (ed.): Pharmacology and Physiology in Anesthetic Practice. Lippincott Williams & Wilkins, Philadelphia. 77–112
TAYLOR POLLY M., HOULTON JOHN E. F. (1984): Post-operative analgesia in the dog: a comparison of morphine, buprenorphine and pentazocine. Journal of Small Animal Practice, 25, 437-451 https://doi.org/10.1111/j.1748-5827.1984.tb03416.x
Unlugenc H. (2003): Pre-emptive analgesic efficacy of tramadol compared with morphine after major abdominal surgery. British Journal of Anaesthesia, 91, 209-213 https://doi.org/10.1093/bja/aeg163