Acute stress-induced changes in hormone and lipid levels in mouse plasma

https://doi.org/10.17221/8718-VETMEDCitation:Ahn T., Bae C.-., Yun C.-. (2016): Acute stress-induced changes in hormone and lipid levels in mouse plasma. Veterinarni Medicina, 61: 57-64.
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We evaluated the conventional acute stress model in mice and investigated the stress-induced changes in concentrations of plasma lipids and hormones such as corticosterone (CORT), insulin, glucagon, triiodothyronine (T3), and thyroxine (T4). Stress induction for 120 min using tape-immobilisation and restraint resulted in an increase in the plasma levels of CORT, insulin, glucose, total cholesterol (TC), and low density lipoprotein-cholesterol compared with unstressed mice. Stress also resulted in a decrease in the concentrations of T3, T4, triglycerides (TG), and high density lipoprotein-cholesterol. However, the amount of glucagon did not change. Moreover, the concentrations of T3, T4, TC, TG, and lipoprotein cholesterol were maintained at constant levels over the recovery periods after stress induction; however, CORT, glucose, and insulin concentrations decreased as a function of time. Statistical correlations between the parameters that changed in response to acute stress were also investigated. In contrast, stress induction for 30 or 60 min did not cause substantial changes in the lipid profiles, although there were fluctuations in the levels of some hormones. This study thus introduces an appropriate model for the study of the acute stress response of lipids and hormones and our data suggest that acute stress affects the levels of plasma lipids, especially cholesterol, in mice.

References:
Armario A., Montero J.L., Balasch J. (1986): Sensitivity of corticosterone and some metabolic variables to graded levels of low intensity stresses in adult male rats. Physiology & Behavior, 37, 559-561  https://doi.org/10.1016/0031-9384(86)90285-4
 
BARLOW S. M., MORRISON P. J., SULLIVAN F. M. (1975): EFFECTS OF ACUTE AND CHRONIC STRESS ON PLASMA CORTICOSTERONE LEVELS IN THE PREGNANT AND NON-PREGNANT MOUSE. Journal of Endocrinology, 66, 93-99  https://doi.org/10.1677/joe.0.0660093
 
Buttemer WilliamA., Astheimer LeeB., Wingfield JohnC. (1991): The effect of corticosterone on standard metabolic rates of small passerine birds. Journal of Comparative Physiology B, 161, -  https://doi.org/10.1007/BF00260804
 
Cyr Nicole E., Earle Kristen, Tam Christine, Romero L. Michael (2007): The effect of chronic psychological stress on corticosterone, plasma metabolites, and immune responsiveness in European starlings. General and Comparative Endocrinology, 154, 59-66  https://doi.org/10.1016/j.ygcen.2007.06.016
 
Dallman MF, Bhatnagar S (2001): Chronic stress and energy balance: role of the hypothalamic-pituitary-adrenal axes. In: McEwen BS (ed.): Handbook of physiology. Oxford University Press, New York. 179−210.
 
Dominguez Gaelle, Faucher Pierre, Henkous Nadia, Krazem Ali, Piérard Christophe, Béracochéa Daniel (2014): Stress induced a shift from dorsal hippocampus to prefrontal cortex dependent memory retrieval: role of regional corticosterone. Frontiers in Behavioral Neuroscience, 8, -  https://doi.org/10.3389/fnbeh.2014.00166
 
DUNN A, SWIERGIEL A (2005): Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice. Pharmacology Biochemistry and Behavior, 81, 688-693  https://doi.org/10.1016/j.pbb.2005.04.019
 
Freake HC, Oppenheimer JH (1995): Thermogenesis and thyroid function. Annual Review of Nutrition 15, 263−291.
 
Füchsl Andrea M., Uschold-Schmidt Nicole, Reber Stefan O. (2013): Chronic psychosocial stress in male mice causes an up-regulation of scavenger receptor class B type 1 protein in the adrenal glands. Stress, 16, 461-468  https://doi.org/10.3109/10253890.2013.793303
 
Gao Xiaoling, Zeng Yuaner, Liu Shuqiang, Wang Shuling (2013): Acute stress show great influences on liver function and the expression of hepatic genes associated with lipid metabolism in rats. Lipids in Health and Disease, 12, 118-  https://doi.org/10.1186/1476-511X-12-118
 
Grégoire Francine, Genart Christine, Hauser Nadine, Remacle Claude (1991): Glucocorticoids induce a drastic inhibition of proliferation and stimulate differentiation of adult rat fat cell precursors. Experimental Cell Research, 196, 270-278  https://doi.org/10.1016/0014-4827(91)90261-R
 
Helmreich DL, Tylee D (2011): Thyroid hormone regulation by stress and behavioral differences in adult male rats. Hormones and Behavior 60, 284−291.
 
Hidalgo Juan, Armario Antonio, Flos Rosa, Dingman Allen, Garvey Justine S. (1986): The influence of restraint stress in rats on metallothionein production and corticosterone and glucagon secretion. Life Sciences, 39, 611-616  https://doi.org/10.1016/0024-3205(86)90041-X
 
Leung K, Munck A (1975): Peripheral Actions of Glucocorticoids. Annual Review of Physiology, 37, 245-272  https://doi.org/10.1146/annurev.ph.37.030175.001333
 
Malisch Jessica L., Saltzman Wendy, Gomes Fernando R., Rezende Enrico L., Jeske Daniel R., Garland Jr. Theodore (2007): Baseline and Stress‐Induced Plasma Corticosterone Concentrations of Mice Selectively Bred for High Voluntary Wheel Running. Physiological and Biochemical Zoology, 80, 146-156  https://doi.org/10.1086/508828
 
Mason Steven R., Ward Leigh C., Reilly Paul E.B. (1992): Fluorimetric detection of serum corticosterone using high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 581, 267-271  https://doi.org/10.1016/0378-4347(92)80280-4
 
McAuley K. A., Williams S. M., Mann J. I., Walker R. J., Lewis-Barned N. J., Temple L. A., Duncan A. W. (2001): Diagnosing Insulin Resistance in the General Population. Diabetes Care, 24, 460-464  https://doi.org/10.2337/diacare.24.3.460
 
PareWP, Giavin GB (1986): Restraint stress in biomedical research: a review. Neuroscience and Biobehavioral Reviews 10, 339−370.
 
Peckett Ashley J., Wright David C., Riddell Michael C. (2011): The effects of glucocorticoids on adipose tissue lipid metabolism. Metabolism, 60, 1500-1510  https://doi.org/10.1016/j.metabol.2011.06.012
 
Remage-Healey L, Romero LM (2001): Corticosterone and insulin interact to regulate glucose and triglyceride levels during stress in a bird. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 281, R994−R1003.
 
Romeo Russell D., Karatsoreos Ilia N., Ali Ferhina S., McEwen Bruce S. (2007): The effects of acute stress and pubertal development on metabolic hormones in the rat. Stress: The International Journal on the Biology of Stress, 10, 101-106  https://doi.org/10.1080/10253890701204270
 
Sánchez Olga, Arnau Anna, Pareja Miguel, Poch Enric, Ramírez Ignasi, Soley Maria (2002): Acute stress-induced tissue injury in mice: differences between emotional and social stress. Cell Stress & Chaperones, 7, 36-  https://doi.org/10.1379/1466-1268(2002)007<0036:ASITII>2.0.CO;2
 
Simon J (1984): Effects of daily corticosterone injections upon plasma glucose, insulin, uric acid and electrolytes and food intake pattern in the chicken. Diabetes and Metabolism 10, 211−217.
 
Starzec James J., Berger David F., Hesse Ralph (1983): Effects of Stress and Exercise on Plasma Corticosterone, Plasma Cholesterol, and Aortic Cholesterol Levels in Rats. Psychosomatic Medicine, 45, 219-226  https://doi.org/10.1097/00006842-198306000-00004
 
Stigler Stephen M. (1989): Francis Galton's Account of the Invention of Correlation. Statistical Science, 4, 73-79  https://doi.org/10.1214/ss/1177012580
 
Sutanto W., de Kloet E. R. (1994): The use of various animal models in the study of stress and stress-related phenomena. Laboratory Animals, 28, 293-306  https://doi.org/10.1258/002367794780745092
 
Wack Corina L., DuRant Sarah E., Hopkins William A., Lovern Matthew B., Feldhoff Richard C., Woodley Sarah K. (2012): Elevated plasma corticosterone increases metabolic rate in a terrestrial salamander. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 161, 153-158  https://doi.org/10.1016/j.cbpa.2011.10.017
 
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